Photocatalytic Decomposition of Metoprolol and Its Intermediate Organic Reaction Products: Kinetics and Degradation Pathway

Abstract

High purity metoprolol prepared by neutraliza-tion of an aqueous solution of metoprolol tartrate is efficiently mineralized to CO2 and water by photocatalysis with TiO2, UV light and a constant flow rate of oxygen. Since the tartrate anions were eliminated, all the HO•generated by photocatalysis reacted efficiently with the aromatic part of the medication. The reaction pathway includes two routes of degradation. The first one includes the transformation of metoprolol to hydroquinone via formation of 4-(2-methoxyethyl)phenol, 2-(4-hydroxyphe-nyl)ethanol and 4-hydroxybenzaldehyde. Metoprolol is also degraded directly to hydroquinone. Then, this aro-matic compound is oxidized to 1,2,4-benzenetriol, which is rapidly oxidized to low molecular weight organic acids before being completely mineralized to CO2 and water. Kinetic studies indicated that the initial reaction rate of the degradation of metoprolol, 4-(2ethoxyethyl)phenol, 2-(4-hydroxyphenyl)ethanol and 4-hydroxybenzaldehyde is described by the LH-HW model.