The benefits of implementing Demand Response (DR) programs in large consumers have been widely documented. However, it is still necessary to explore in more detail the impacts of the implementation of these programs in residential users on the benefits of the distribution system operators. In this paper, we determine the effects of Demand Response (DR) on the reconfiguration of a distribution system considering the consumption characteristics of residential users in Colombia. For this purpose, the demand curve of a typical residential user was constructed for Bogotá D.C., and measurements were taken to estimate the participation of this user in a DR program. In addition, an algorithm based on Particle Swarm Optimization is used as a solution strategy for the reconfiguration problem. The results show that a distribution system reconfiguration could significantly increase the revenues obtained by a Network Operator. However, it is shown that the reduction of energy losses obtained from the DR would not provide sufficient incentives for them to promote the participation of residential users in this kind of programs.