Objective To analyze public policies of zoonosis in Colombia, in the period of 1975 to 2014, as State responses. Methodology Used the policy cycle analysis approach or sequential approach. This analysis was carried out by means of the following aspects: content, processes, actors, and vertical and horizontal relationships between policies. Results Zoonosis policies were very different in scope, contents and forms, and results are part of a history of successes and failures, who have only managed to partially transform the general and regional overview of the zoonosis. Conclusions The implementation of decisions that have operational scope is relatively slow and scattered in areas of zoonosis in the country. A major achievement has been the shift from policies that are individualized to the great policy of health environmental-PISA.