A Synthesis of 4-Chloro-2-(trichloromethyl)pyrimidines and Their Study in Nucleophilic Substitution

dc.creatorTRUJILLO LAGUNAS, MICHELLE LIZBETH; 783401
dc.creatorMEDINA MERCADO, IGNACIO; 701363
dc.creatorZARAGOZA GALICIA, IVANN; 231282
dc.creatorOlivo, Horacio;#0000-0002-8082-5285
dc.creatorROMERO ORTEGA, MOISES; 14987
dc.creatorTRUJILLO LAGUNAS, MICHELLE LIZBETH
dc.creatorMEDINA MERCADO, IGNACIO
dc.creatorZARAGOZA GALICIA, IVANN
dc.creatorOlivo, Horacio
dc.creatorROMERO ORTEGA, MOISES
dc.date2019-03-14T17:29:42Z
dc.date2019-03-14T17:29:42Z
dc.date2019-01-15
dc.date.accessioned2022-10-12T23:31:58Z
dc.date.available2022-10-12T23:31:58Z
dc.identifier0039-7881
dc.identifierhttp://hdl.handle.net/20.500.11799/99612
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4149777
dc.descriptionEn el presente manuscrito se presenta un método nuevo para la preparación de tetracloropirimidinas y se presenta un estudio acerca de su reactividad química.
dc.descriptionA convenient two-step synthesis of 2-trichloromethyl-4-chloropyrimidines starting from 2-trichloromethyl-1,3-diazabutadienes is described. These nitrogen heterocycles were prepared in one pot synthesis by a sequential acylation/intramolecular cyclization reaction between 2-trichloromethyl-1,3-diazabutadienes and acyl chlorides in the presence of triethylamine followed by treatment with POCl3. This is the first report for the synthesis of this type of 2-trichloromethyl-4-chloropyrimidine derivatives and serves as a source for a wide variety of other substituted pyrimidines by nucleophilic substitution reactions.
dc.descriptionConacyt
dc.languageeng
dc.publisherThieme
dc.rightsopenAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectCycloaddition reaction
dc.subjecttetrachloropyrimidines
dc.subject1,3-diazadienes
dc.subjectintramolecular cyclization
dc.subjectnucleophilic substitution.
dc.subjectBIOLOGÍA Y QUÍMICA
dc.titleA Synthesis of 4-Chloro-2-(trichloromethyl)pyrimidines and Their Study in Nucleophilic Substitution
dc.typeArtículo
dc.typearticle


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