Synthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties

Synthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties

dc.creatorPLATA VARGAS, EDUARDO; 811740
dc.creatorDe la Cruz Hernández, Cinthia Yareli;#0000-0002-3169-8144
dc.creatorDORAZCO GONZALEZ, ALEJANDRO; 205445
dc.creatorFUENTES NORIEGA, INES; 253114
dc.creatorMORALES MORALES, DAVID; 19259
dc.creatorGERMAN ACACIO, JUAN MANUEL; 102452
dc.creatorPLATA VARGAS, EDUARDO
dc.creatorDe la Cruz Hernández, Cinthia Yareli
dc.creatorDORAZCO GONZALEZ, ALEJANDRO
dc.creatorFUENTES NORIEGA, INES
dc.creatorMORALES MORALES, DAVID
dc.creatorGERMAN ACACIO, JUAN MANUEL
dc.date2019-01-17T23:42:29Z
dc.date2019-01-17T23:42:29Z
dc.date2017
dc.date.accessioned2022-10-12T23:28:24Z
dc.date.available2022-10-12T23:28:24Z
dc.identifierhttp://www.redalyc.org/articulo.oa?id=47553303004
dc.identifierhttp://hdl.handle.net/20.500.11799/97057
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4149669
dc.descriptionThe reaction by melt mixing at 220 °C of the antihypergly-cemic drug metformin hydrochloride1with dehydrated sodium suc-cinate yields efficiently the organic salt [MET]2[SUC]2(H-MET+=metforminium and SUC2-= succinate). Solid state CPMAS NMR13Cspectroscopy experiments, powder X-ray diffraction and FT-IR re-sults support the formation of the pharmaceutical salt2in goodyields. Besides, thecharged-assisted hydrogen bonding interactionsof type N-H...-O(carboxylate) were thoroughly analyzed by singlecrystal X-Ray diffraction techniques. Thus, the pharmaceutical salt2possesses considerable thermal differences when compared to thepure starting reagents. In addition, intrinsic dissolution rate expe-riments in buffered aqueous solutions at pH= 6.8 showed a sus-tained-release behavior of the drug in2with a constant value ofKint= 0.885 mg/min * cm2.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Química de México
dc.relationhttp://www.redalyc.org/revista.oa?id=475
dc.rightsJournal of the Mexican Chemical Society
dc.rightsopenAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceJournal of the Mexican Chemical Society (México) Num.3 Vol.61
dc.subjectQuímica
dc.subjectDiabetes
dc.subjectMetformin
dc.subjectX-ray structures
dc.subjectssCPMAS NMR13C
dc.subjectMelting
dc.subjectSuccinate
dc.subjectmechanochemistry
dc.subjectgreen chemistry
dc.subjectQuímica
dc.subjectDiabetes
dc.subjectMetformin
dc.subjectX-ray structures
dc.subjectssCPMAS NMR13C
dc.subjectMelting
dc.subjectSuccinate
dc.subjectmechanochemistry
dc.subjectgreen chemistry
dc.subjectBIOLOGÍA Y QUÍMICA
dc.titleSynthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties
dc.titleSynthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties
dc.typeArtículo
dc.typeArtículo
dc.typearticle


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