Experimental-Theoretic Approach to Drug-Lymphocyte Interactome Networks with Flow Cytometry and Spectral Moments Perturbation Theory

dc.creatorTENORIO BORROTO, ESVIETA; 335911
dc.creatorRIVERA RAMIREZ, FABIOLA; 131095
dc.creatorVAZQUEZ CHAGOYAN, JUAN CARLOS; 120705
dc.creatorMONTES DE OCA JIMENEZ, ROBERTO; 14327
dc.creatorGarcia-Mera, Xerardo;#0000-0001-5218-6351
dc.creatorGONZALEZ DIAZ, HUMBERTO;x1342236
dc.creatorTENORIO BORROTO, ESVIETA
dc.creatorRIVERA RAMIREZ, FABIOLA
dc.creatorVAZQUEZ CHAGOYAN, JUAN CARLOS
dc.creatorMONTES DE OCA JIMENEZ, ROBERTO
dc.creatorGarcia-Mera, Xerardo
dc.creatorGONZALEZ DIAZ, HUMBERTO
dc.date2018-03-13T00:54:19Z
dc.date2018-03-13T00:54:19Z
dc.date2016-08-06
dc.date.accessioned2022-10-12T23:20:22Z
dc.date.available2022-10-12T23:20:22Z
dc.identifier1381-6128
dc.identifierhttp://hdl.handle.net/20.500.11799/79878
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4149585
dc.descriptionModelos matematicos y citometria de flujo
dc.descriptionAbstract: We can combine experimental techniques like Flow Cytometry Analysis (FCA) with Chemoinformatics methods to predict the complex networks of interactions between organic compounds and targets in the immune system. In this work, we determined experimentally the values of EC50 = 17.82 μg/mL and Cytotoxicity = 20.6 % for the antimicrobial / anti-parasite drug Dermofural over Balb/C CD9 lymphocytes using flow cytometry. After that, we developed a new Perturbation-theory model for Drug-Cell Target Interactome in Lymphocytes based on dispersion-polarization moments of drug structure. The models correctly classifies 34591 out of 42715 (Accuracy = 80.9%) cases of perturbations in assay endpoints of 11492 drugs (including both train and validation series). Each endpoint correspond to one out of 2616 assays, 38 molecular and cellular targets, 77 standard type measures, in four possible (human and rodents
dc.descriptionCONACYT
dc.languageeng
dc.publisherCurrent Pharmaceutical Design
dc.relation22;
dc.rightsopenAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectFlow cytometry
dc.subjectElectronic charge
dc.subjectAtomic Polarizability
dc.subjectDipole Moment
dc.subjectSpectral moments
dc.subjectPerturbation theory
dc.subjectComplex networks
dc.subjectCIENCIAS SOCIALES
dc.titleExperimental-Theoretic Approach to Drug-Lymphocyte Interactome Networks with Flow Cytometry and Spectral Moments Perturbation Theory
dc.typeArtículo
dc.typearticle


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