Tesis
Modificações morfológicas placentárias durante a infecção crônica por Leishmania amazonensis em modelo murino
Fecha
2018-10-11Registro en:
FARIA, Mariana Gaspar Botelho Funari de. Modificações morfológicas placentárias durante a infecção crônica por Leishmania amazonensis em modelo murinho. 2018. 54 f. Dissertação (Mestrado em Imunologia e Parasitologia Básicas e Aplicadas) - Universidade Federal de Mato Grosso, Instituto de Ciências Biológicas e da Saúde, Barra do Garças, 2018.
Autor
Souto, Paula Cristina de Souza
Vitorino, Fernanda Regina Casagrande Giachini
http://lattes.cnpq.br/3100345884689140
http://lattes.cnpq.br/2161765071682282
Souto, Paula Cristina de Souza
277.680.138-10
http://lattes.cnpq.br/2161765071682282
Américo, Madileine Francely
267.529.008-41
http://lattes.cnpq.br/4097128727139521
277.680.138-10
712.962.121-49
Silva, Wagner Welber Arrais da
151.634.898-28
http://lattes.cnpq.br/0538721794248574
Institución
Resumen
Leishmaniasis belongs to a group of infectious and endemic diseases. Several infectious
diseases can affect pregnancy, causing placental and fetal changes. However little is
known how the tegumentary leishmaniasis, affects the gestation. The placental barrier
determines the progress of infections. The placental barrier determines the progress of
infections. Thus, the proposal of this study was To analyze the possible influences of
Leishmania amazonensis infection on the pregnancy of BALB / c female mice For this,
BALB /c females, divided into control group (n = 5) and infected group (n = 5) were used.
At the 8th week of life, in the infected group, the amastigote forms of the parasite L.
amazonensis were infected. After 8 weeks of infection, at the 16th week of life, females
were submitted to mating. At 20 days of pregnancy, females were euthanized and the
number of resorptions, fetal weight, and placentas collected, weighed and processed for
morphological and morphometric analysis. The results of the number of fetuses,
resorptions and placental efficiency did not show differences between groups. However,
morphometric and morphological analysis showed important differences between groups.
It can be observed that the mean areas of decidua, labyrinth and junctional zone of the
control group were significantly higher in comparison to those in the infected group, there
was also a breakdown in the morphological structure, with loss of delimitation between
the areas in the infected group, mainly in the labyrinthine region Thus, the results showed
placental changes that may compromise fetal development. However, further studies are
necessary for the full understanding of pregnancy impairment during tegumentary
leishmaniasis.