Tesis
Doença renal crônica : a evolução da patologia associada à citocinas e fatores bioquímicos
Fecha
2016-02-19Registro en:
ALVES, Josilene Dália. Doença renal crônica: a evolução da patologia associada à citocinas e fatores bioquímicos. 2016. 96 f. Dissertação (Mestrado em Imunologia e Parasitologia Básicas e Aplicadas) - Universidade Federal de Mato Grosso, Instituto de Ciências Biológicas e da Saúde, Barra do Garças, 2016.
Autor
Lima, Victor Vitorino
Vitorino, Fernanda Regina Casagrande Giachini
http://lattes.cnpq.br/3100345884689140
http://lattes.cnpq.br/7503102443670435
Lima, Victor Vitorino
005.356.961-08
http://lattes.cnpq.br/7503102443670435
Brune, Maria Fernanda Spegiorin Salla
025.278.569-00
http://lattes.cnpq.br/6490966175710971
005.356.961-08
712.962.121-49
Lobato, Núbia de Souza
717.037.801-91
http://lattes.cnpq.br/1922970859216238
Institución
Resumen
Chronic kidney disease (CKD) is currently considered a problem of global public health. In
the later stages, the CKDis mainly characterized by dysfunction of the immune system and
alterations in lipid metabolism and minerals. These complications contribute directly to higher
rates of morbidity and mortality of these patients. This study aims to investigate possible
associations between cytokines and potassium, calcium, phosphorus, total cholesterol and
High Density Lipoproteins (HDL), cholesterol in patients with advanced stages of CKD.
Serum measurements of total and HDL cholesterol, potassium, calcium, phosphorous, as well
as the estimated GFR (glomerular filtration rate) were performed. Quantification of cytokines
was performed by cytometry. Statistical differences were evaluated by ANOVA or Kruskal-
Wallis test, when indicated. Correlations were analyzed using the Pearson or Spearman test,
when apropriated. For this study were considered significant p values <0.05. The study
included 92 participants between control subjects and patients with CKD from stages 3, 4 and
5. The results of this study show that serum concentrations of potassium, phosphorus, total
cholesterol and HDL cholesterol, as well as IL-6, INF-γ and IL-17A expression are altered in
patients with CKD in advanced stages, when compared to the control group, and that these
changes tend to get worse as CKD progresses. As IL-6, INF-γ andIL-17A levels increase, so
does the serum potassium, phosphorus and total cholesterol, while HDL cholesterol and GFR
decline. Besides, potential biomarkers it is possible that these cytokines may become targets
for novel immunomodulatory therapies. Our results provide new evidence that CKD patients
must be carefully monitored, intendingto reduce their risk for cardiovascular disease, as well
as to retard the progression of CKD.