| dc.creator | Campos E,Carolina | |
| dc.creator | Cavieres,M. Fernanda | |
| dc.date | 2011-05-01 | |
| dc.date.accessioned | 2017-03-07T16:38:56Z | |
| dc.date.available | 2017-03-07T16:38:56Z | |
| dc.identifier | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000500008 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/405185 | |
| dc.description | Background: Approximately 15% of misoprostol-induced-abortions may not be successful, leading to in utero exposure to the drug and to the induction of a series of defects including central nervous system, limb and visceral defects. A commonproposal is that the drug causes disruption of the fetal vasculature leading to embryonic or fetal hypoxia. Aim: To evaluate the teratogenicity of misoprostol using the rat post-implantation embryo culture. Material and Methods: Rat embryos were collected at the beginning of organogenesis and cultured in rat serum containing misoprostol at concentrations of 200, 2,000 or 20,000 pg/ml. Functionality, morphology and morphometry parameters were evaluated. Results: Misoprostol induced a dose-dependent embryotoxic effect causing a decrease in embryo viability and function (poor vascular development and survival) and morphometry (alterations in branchial arches, heart and cephalic portions of the neural tube, among others). Conclusions: All the manifestations observed are indicative of the ability of misoprostol to directly induce developmental retardation and alterations. | |
| dc.format | text/html | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.source | Revista médica de Chile v.139 n.5 2011 | |
| dc.subject | Embryo culture techniques | |
| dc.subject | Misoprostol | |
| dc.subject | Teratology | |
| dc.subject | Toxicpotential | |
| dc.title | Evaluación de la embriotoxicidad de misoprostol utilizando el ensayo cultivo de embriones postimplantación | |
| dc.type | Artículos de revistas | |
