Inhibición de la proteína de transferencia de ésteres de colesterol para el manejo de la enfermedad cardiovascular ateroesclerótica: el segundo acto &#34;Una esperanza que renace&#34;

Arteaga,Antonio; Rigotti,Attilio

dc.creator	Arteaga,Antonio
dc.creator	Rigotti,Attilio
dc.date	2011-06-01
dc.date.accessioned	2017-03-07T16:38:37Z
dc.date.available	2017-03-07T16:38:37Z
dc.identifier	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000600016
dc.identifier.uri	http://repositorioslatinoamericanos.uchile.cl/handle/2250/405103
dc.description	Despite the clinical use of statins to reduce serum levels of LDL cholesterol and treat atherosclerotic cardiovascular disease, a high proportion of patients remain at significant residual cardiovascular risk. In this context, low HDL cholesterol levels are an additional risk factor and intervention studies suggest that a fraction of the cardiovascular protection achieved with pharmacotherapy is explained specifically by the increase in serum levels of HDL cholesterol. Pharmacological inhibitors of the cholesteryl ester transfer protein (CETP) can induce a significant elevation in HDL cholesterol and, potentially, lead to better control of residual cardiovascular risk beyond the benefit demonstrated by statins. While the use of torcetrapib had unexpected side effects, dalcetrapib and anacetrapib are new CETP inhibitors with a better safety profile and are currently under study to evaluate their effects on vascular lesions and clinical events in patients at high cardiovascular risk. If these studies show positive findings, we will witness a new biomedical advance as significant as was the clinical.
dc.format	text/html
dc.language	es
dc.publisher	Sociedad Médica de Santiago
dc.source	Revista médica de Chile v.139 n.6 2011
dc.subject	Cholesterol ester transfer proteins
dc.subject	Cholesterol
dc.subject	HDL
dc.subject	Heart diseases
dc.title	Inhibición de la proteína de transferencia de ésteres de colesterol para el manejo de la enfermedad cardiovascular ateroesclerótica: el segundo acto "Una esperanza que renace"
dc.type	Artículos de revistas

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Inhibición de la proteína de transferencia de ésteres de colesterol para el manejo de la enfermedad cardiovascular ateroesclerótica: el segundo acto &#34;Una esperanza que renace&#34;

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Inhibición de la proteína de transferencia de ésteres de colesterol para el manejo de la enfermedad cardiovascular ateroesclerótica: el segundo acto "Una esperanza que renace"