dc.creatorMartin,Carolina
dc.creatorSolís,Loretto
dc.creatorConcha,Margarita I
dc.creatorOtth,Carola
dc.date2011-06-01
dc.date.accessioned2017-03-07T16:38:37Z
dc.date.available2017-03-07T16:38:37Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000600013
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/405100
dc.descriptionHerpes simplex virus type 1 (HSV-1) is ubiquitous, neurotropic, and the most common pathogenic cause of sporadic acute encephalitis in humans. Herpes simplex encephalitis is associated with a high mortality rate and significant neu-rological, neuropsychological, and neurobehavioral sequels. HSV-1 infects limbic system structures in the central nervous system (CNS), and has been suggested as an environmental risk factor for Alzheimer s disease. The possibility that HSV-1 reactivates in CNS neurons causing chronic progressive damage at cellular level and altering the neuronal functionality has not been thoroughly investigated. Currently it is ignored if recurrent reactivation of HSV-1 in asymptomatic patients involves some risk of progressive deterioration of the CNS functions caused, in example, by a neuroinflammatory response against the virus or by direct toxicity of the pathogen on neurons. Therefore, studies regarding the routes of dissemination of HSV-1 from the peripheral ganglions to the CNS, as well as the possible cellular and molecular mechanisms implied in generating neuronal damage during latent and productive infection, are of much relevance.
dc.formattext/html
dc.languagees
dc.publisherSociedad Médica de Santiago
dc.sourceRevista médica de Chile v.139 n.6 2011
dc.subjectAlzheimer disease
dc.subjectEncephalitis
dc.subjectviral
dc.subjectHerpesvirus 1
dc.subjecthuman
dc.titleHerpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de Alzheimer
dc.typeArtículos de revistas


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