| dc.creator | Horta,Fabrizzio | |
| dc.creator | Madariaga,Marcia | |
| dc.creator | García,Alejandra | |
| dc.creator | Hartel,Steffen | |
| dc.creator | Smith,Rosita | |
| dc.date | 2011-03-01 | |
| dc.date.accessioned | 2017-03-07T16:37:58Z | |
| dc.date.available | 2017-03-07T16:37:58Z | |
| dc.identifier | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000300004 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/404926 | |
| dc.description | Background: There is an association between aging ana an increased number ofsperms with alterations in nuclear DNA. Aim: To study the association between age and fragmentation of sperm DNA. Material andMethods: Sixty two volunteers provided semen for analysis. These were separated in a group aged less than forty years and a second group aged more than forty years. Sperm DNA fragmentation was studied by TÚNEL (terminal deoxynucleotidyl transferase-mediated2'-deoxyuridine 5'-triphosphate nick end-labeling) and SCD (sperm chromatin dispersión test) assays. Results: Compared with theiryounger counterparts, patients aged more than 40years had a higher proportion ofsperms with DNA fragmentation by TÚNEL (20 ±1.3 and24 ± 1.9% respectively, p < 0.05) and SCD (22 ± 1.4 and26 ± 1.6% respectively, p < 0.05). The results ofboth assays had a correlation coefficientofO.8. No differences between groups were observed for other seminal parameters. Conclusions: Sperm DNA fragmentation increases with age in males. | |
| dc.format | text/html | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.source | Revista médica de Chile v.139 n.3 2011 | |
| dc.subject | Aging | |
| dc.subject | DNA fragmentation | |
| dc.subject | Spermatozoa | |
| dc.title | Aumento del daño en el ADN espermático en varones mayores de 40 años | |
| dc.type | Artículos de revistas | |
