dc.creatorTORRES V,PABLO
dc.creatorSEPÚLVEDA C,M. JACQUELINE
dc.creatorVON PLESSING R,CARLOS
dc.date2011-01-01
dc.date.accessioned2017-03-07T16:35:44Z
dc.date.available2017-03-07T16:35:44Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000100019
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/404301
dc.descriptionA new, simplified solid phase extraction procedure for the determination of risperidone and 9-hydroxyrisperidone in human plasma has been developed. This method involves the use of an optimized extraction protocol developed in Waters OASIS® HLB 30mg 1cc extraction columns using 1 mL of human serum. Separation was performed by HPLC using a Waters XTerra RP-18 (5 µm, 150x4,6 mm) column with a mobile phase consisting in acetonitrile - potassium dihydrogen phosphate 50 mM pH 3.4 (27/73). UV detection at 278 nm was used to quantify analytes, encountering good linearity (r² > 0.999) in the 2-100 ng/mL concentration range. The mean recovery was 92.4 % and 92.8 % for risperidone and 9-hydroxyrisperidone respectively, with an intraday - interday precision below 7%, and accuracy below 115 %. The method has been successfully applied in pharmacokinetic studies that require a large sample number.
dc.formattext/html
dc.languageen
dc.publisherSociedad Chilena de Química
dc.sourceJournal of the Chilean Chemical Society v.56 n.1 2011
dc.subjectRisperidone
dc.subject9-hydroxyrisperidone
dc.subjectsolid phase extraction
dc.titlePHARMACOKINETIC STUDY OF RISPERIDONE: APPLICATION OF A HPLC METHOD WITH SOLID PHASE EXTRACTION
dc.typeArtículos de revistas


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