Síntese, caracterização e aplicação de novos complexos derivados do piridoxal como miméticos na superóxido dismutase e peroxidases

Abstract

This work describes the synthesis, characterization and application of complexes containing metals of transition. The synthesis of ligands (Bases of Schiff) was carried out from pyridoxal hydrochloride, salicylic aldehyde, dihydrazides and primary amines with aliphatic or aromatic chains, and metallic salts of chloride, perchlorate and acetylacetonate for the synthesis of complexes. The synthesized compounds were 1-[Mn2(L1)2](ClO4)2(Cl)2(H2O)2; 2- Ni2(L1)2](ClO4)2(Cl)2; 3-[V2O2(L1)(CH3O)2]; 4-[Fe2(L2)2](Cl)4(H2O)2; 5-[V2O4(L3)](DBUH) 2; 6-[V2O4(L4)](Et3N-H)2; 7-[Ni2(L5)(Cl)(H2O)5](ClO4)Cl(H2O)3; 8- [Ni3(L6)3](ClO4)4Cl(H2O)4; 9- [Cu2(L6)(ClO4)2(H2O)4](ClO4)2(H2O)2; 10- [Ni(L7)](2H2O) 11- [Fe(L7)](ClO4)(H2O). The structural study of these compounds was accomplished in the solid state using the X-ray diffraction on single crystal. The tests superoxide dismutase activity (SOD) and peroxidase of complexes was determined spectrophotometrically. In addition, all compounds were characterized by infrared spectroscopy. To identify the oxidation state of some complexes the electron paramagnetic resonance (EPR) was used.