Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats.: I. Reproductive Damage

dc.creatorArteaga-Martínez,Manuel
dc.creatorGarcía-Peláez,Isabel
dc.creatorAguirre-Luna,Oswaldo M
dc.creatorSaavedra-Ontiveros,Dolores
dc.date2010-12-01
dc.date.accessioned2017-03-07T16:33:33Z
dc.date.available2017-03-07T16:33:33Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400016
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/403658
dc.descriptionWe investigated the reproductive damage and teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, which received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. In rats treated with the mixture the number of live fetuses decreased and reabsorptions increased with increasing concentrations of the mixture, as well as the number of abnormal fetuses. We conclude that the ethylene glycol-methyl cellosolve mixture possesses a higher teratogenic potential than each of its constituents separately, producing reproductive damage, external fetal abnormalities, growth delay, and increased fetal death.
dc.formattext/html
dc.languageen
dc.publisherSociedad Chilena de Anatomía
dc.sourceInternational Journal of Morphology v.28 n.4 2010
dc.subjectEthylene glycol
dc.subjectGlycol ethers
dc.subjectMethyl cellosolve
dc.subjectRat fetuses
dc.subjectTeratogenesis
dc.titleTeratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats.: I. Reproductive Damage
dc.typeArtículos de revistas


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