| dc.creator | LAKSHMI,K.S | |
| dc.creator | RAJESH,T | |
| dc.date | 2010-06-01 | |
| dc.date.accessioned | 2017-03-07T16:26:02Z | |
| dc.date.available | 2017-03-07T16:26:02Z | |
| dc.identifier | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200023 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/401544 | |
| dc.description | A simple reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of rosiglitazone (RGL) and gliclazide (GLC) in puré and pharmaceutical dosage forms. Aphenomenex Gemini reverse phase C column (150x4.6mm i.d., 5µ) was used with a mobile phase containing a mixture of acetonitrile and water (pH 3 adjusted with ortho phosphoric acid) in the ratio of 70: 30. The flow rate was 0.6mL/min. and effluents were monitored at 250nm and eluted at 2.41min. (RGL) and 5.22min. (GLC). Calibration curve was plotted with a range from 0.025-2.5µg/mL for RGL and 0.08 to 8µg/mL for GLC. The assay was validated for the parameters like accuracy (>97.87% recovery), precision (intra-day and inter-day with %RSD < 2), robustness and system suitability parameters. Henee the method was found to suitable for the routine quality control of the drugs in puré and pharmaceutical dosage forms. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad Chilena de Química | |
| dc.source | Journal of the Chilean Chemical Society v.55 n.2 2010 | |
| dc.subject | Rosiglitazone | |
| dc.subject | Gliclazide | |
| dc.subject | RP-HPLC | |
| dc.subject | validation | |
| dc.subject | Pharmaceutical dosage forms | |
| dc.title | SIMULTANEOUS DETERMINATION OF ROSIGLITAZONE AND GLICLAZIDE IN PHARMACEUTICAL DOSAGE FORMS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY | |
| dc.type | Artículos de revistas | |
