STABILITY-INDICATING RP-HPLC METHOD FOR ANALYSIS OF ATORVASTATIN IN BULK DRUG, MARKETED TABLET AND NANOEMULSION FORMULATION

dc.creatorMUSTAFA,GULAM
dc.creatorAZEEM,ADNAN
dc.creatorAHMAD,FARHAN J
dc.creatorKHAN,ZEENAT I
dc.creatorSHAKEEL,FAIYAZ
dc.creatorTALEGAONKAR,SUSHMA
dc.date2010-06-01
dc.date.accessioned2017-03-07T16:25:58Z
dc.date.available2017-03-07T16:25:58Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200008
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/401529
dc.descriptionA simple, highly sensitive, isocratic stability indicating reversed phase-high performance liquid chromatography (RP-HPLC) method with UV detection at 247 nm was developed and validated for analysis of atorvastatin (AT). Retention time of the AT was found to be 4.02 min. A mobile phase consisting of 0.05 M sodium phosphate buffer and methanol (3:7 v/v) pH 4.1 at flow rate of lµL/min was employed in this study. The calibration curves were linear with regression coefficient (r²) of 0.9997 ± 0.0014. The limits of detection (LOD) and the limits of quantification (LOQ) were found to be 0.20 and 0.60 µg/mL, respectively. The method was statistically validated in accordance with International conference on harmonization (ICH) guidelines. The proposed method was found sensitive, specific and was successfully applied for the estimation of atorvastatin in pharmaceutical formulations (bulk drug, tablet, nanoemulsion).
dc.formattext/html
dc.languageen
dc.publisherSociedad Chilena de Química
dc.sourceJournal of the Chilean Chemical Society v.55 n.2 2010
dc.subjectRP-HPLC
dc.subjectatorvastatin
dc.subjectnanoemulsion
dc.subjecttablets
dc.subjectICH guidelines
dc.titleSTABILITY-INDICATING RP-HPLC METHOD FOR ANALYSIS OF ATORVASTATIN IN BULK DRUG, MARKETED TABLET AND NANOEMULSION FORMULATION
dc.typeArtículos de revistas


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