Artigo de Periódico
Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection
Fecha
2002-07Registro en:
0340-6717
v. 111, n. 1
Autor
Grimaldi, Rogério
Shindo, Nice
Acosta, Angelina Xavier
Dourado, Maria Inês Costa
Brites, Carlos
Bou-Habib, Dumith Chequer
Castro, Bernardo Galvão
Carvalho, Ozenilda de Melo
Brito, Ivo
Grimaldi, Rogério
Shindo, Nice
Acosta, Angelina Xavier
Dourado, Maria Inês Costa
Brites, Carlos
Bou-Habib, Dumith Chequer
Castro, Bernardo Galvão
Carvalho, Ozenilda de Melo
Brito, Ivo
Institución
Resumen
We investigated the occurrence of the CCR5Δ32
mutation in various regional ethnic groups in Brazil and tested the resistance of mutant peripheral blood mononuclear cells (PBMCs) to infection by HIV-1 in vitro. The
heterozygous prevalence was 5.3% in uninfected African descendents and 8.8% in HIV-1-positive individuals (neither population had Δ32/Δ32). German descendents were 11% heterozygous and l% Δ32/Δ32. Amerindians were exclusively CCR5/CCR5. Heterozygous uninfected PBMCs showed partial resistance to R5-HIV-1 strains in vitro, but
no resistance to X4 virus. HIV-1-positive CCR5/CCR5 had higher viral loads than did heterozygous cells.