Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection

dc.creatorGrimaldi, Rogério
dc.creatorShindo, Nice
dc.creatorAcosta, Angelina Xavier
dc.creatorDourado, Maria Inês Costa
dc.creatorBrites, Carlos
dc.creatorBou-Habib, Dumith Chequer
dc.creatorCastro, Bernardo Galvão
dc.creatorCarvalho, Ozenilda de Melo
dc.creatorBrito, Ivo
dc.creatorGrimaldi, Rogério
dc.creatorShindo, Nice
dc.creatorAcosta, Angelina Xavier
dc.creatorDourado, Maria Inês Costa
dc.creatorBrites, Carlos
dc.creatorBou-Habib, Dumith Chequer
dc.creatorCastro, Bernardo Galvão
dc.creatorCarvalho, Ozenilda de Melo
dc.creatorBrito, Ivo
dc.date.accessioned2022-10-07T15:54:47Z
dc.date.available2022-10-07T15:54:47Z
dc.date.issued2002-07
dc.identifier0340-6717
dc.identifierhttp://www.repositorio.ufba.br/ri/handle/ri/7467
dc.identifierv. 111, n. 1
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4006242
dc.description.abstractWe investigated the occurrence of the CCR5Δ32 mutation in various regional ethnic groups in Brazil and tested the resistance of mutant peripheral blood mononuclear cells (PBMCs) to infection by HIV-1 in vitro. The heterozygous prevalence was 5.3% in uninfected African descendents and 8.8% in HIV-1-positive individuals (neither population had Δ32/Δ32). German descendents were 11% heterozygous and l% Δ32/Δ32. Amerindians were exclusively CCR5/CCR5. Heterozygous uninfected PBMCs showed partial resistance to R5-HIV-1 strains in vitro, but no resistance to X4 virus. HIV-1-positive CCR5/CCR5 had higher viral loads than did heterozygous cells.
dc.languageen
dc.sourcehttp://dx.doi.org/10.1007/s00439-002-0747-x
dc.titlePrevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection
dc.typeArtigo de Periódico


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