Seroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de Chile

dc.creatorZubieta,Marcela
dc.creatorSantolaya,María E
dc.creatorHurtado,Carmen
dc.creatorAlvarez,Ana M
dc.creatorAvilés,Carmen L
dc.creatorBecker,Ana
dc.creatorBrahm,Javier
dc.creatorSalgado,Carmen
dc.creatorSilva,Pamela
dc.creatorTopelberg,Santiago
dc.creatorTordecilla,Juan
dc.creatorVaras,Mónica
dc.creatorVillarroel,Milena
dc.creatorViviani,Tamara
dc.date2009-07-01
dc.date.accessioned2017-03-07T16:22:12Z
dc.date.available2017-03-07T16:22:12Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000700007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/400401
dc.descriptionBackground: Children under oncological therapy are at risk of infection by hepatitis B virus (HBV). Aim: To determine the prevalence of infection of HBV in children with cancer who have undergone chemotherapy or have had a hematopoietic stem cell transplant. Material and methods: Collaborative, multi-centric study. Serum samples were collected from 281 children with cancer and episodes of febrile neutropenia, from 6 hospitals belonging to the public health network in the Metropolitan Region, between June 2004 and August 2006. These samples were stored at -70-'C. In September 2006, 200 samples were randomly chosen and 170 analyzed to determine hepatitis B virus surface antigen (HBsAg) and anticore total antibodies (anti HBc) by fluorescent ELISA (Enzyme Linked Immunosorbent Assay). In five cases in which a low volume of sample was available, only one marker was studied (HBsAg in two and anti HBc in three). Results: Samples carne from children aged 4 months to 18 years, 104 males (61%). They had received an average of 38 transfusions (range 3-107) from 65 donors (range 3-345). Twelve children were found positive for some marker of HBV: HBsAg in three (1.8%) and anti HBc in ten (7%). In 5 patients that had negative HBsAg and positive anti HBc, anti surface antigen antibodies (anti HBs) were determined and resulted positive in four Conclusions: The prevalence of HBV in this sample was 7% if both serologic markers are considered and 1.8% if only HBsAg is considered.
dc.formattext/html
dc.languagees
dc.publisherSociedad Médica de Santiago
dc.sourceRevista médica de Chile v.137 n.7 2009
dc.subjectAntineoplastic protocols
dc.subjectBlood component transfusion
dc.subjectHepatitis B virus
dc.titleSeroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de Chile
dc.typeArtículos de revistas


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