SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING

dc.creatorSHAMSUZZAMAN,
dc.creatorSHAHEEN KHAN,MOHD
dc.creatorALAM,MAHBOOB
dc.date2009-12-01
dc.date.accessioned2017-03-07T16:21:31Z
dc.date.available2017-03-07T16:21:31Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400010
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/400226
dc.descriptionThe reaction of cholest-5-en-7-one (1), its 3β-acetoxy (2) and 3β-chloro (3) analogues with thiosemicarbazide in sodium ethoxide affords 2'-thiocarbamoyl-cholest [5,7-cd] pyrazoline (4), 2'-thiocarbamoyl-3β-acetoxycholest [5,7-cd] pyrazoline (5), and 2'-thiocarbamoyl-3β-chloro cholest [5,7-cd] pyrazoline (6), respectively. The structures of the newly synthesized compounds have been established on the basis of physical, analytical and spectral data. Their antibacterial activities were tested in vitro by disk diffusion assay against Gram-positive and Gram-negative bacterial strains of bacteria.
dc.formattext/html
dc.languageen
dc.publisherSociedad Chilena de Química
dc.sourceJournal of the Chilean Chemical Society v.54 n.4 2009
dc.subjectthiosemicarbazide
dc.subjectpyrazolines
dc.subjectcholest-5-en-7-one
dc.subjectthiocarbamoyl
dc.subjectanti-bacterial activity
dc.titleSYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING
dc.typeArtículos de revistas


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