A RP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF DILTIAZEM AND QUINOLONES IN BULK, FORMULATIONS AND HUMAN SERUM

dc.creatorSULTANA,NAJMA
dc.creatorARAYNE,M. SAEED
dc.creatorSHAFI,NIGHAT
dc.creatorNAZ,ASIA
dc.creatorNAZ,SHABANA
dc.creatorSHAMSHAD,HINA
dc.date2009-12-01
dc.date.accessioned2017-03-07T16:21:31Z
dc.date.available2017-03-07T16:21:31Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/400223
dc.descriptionHigh Performance Liquid Chromatographic method was developed and applied for the simultaneous determination of diltiazem and fluoroquinolones in bulk, pharmaceutical formulations and human serum in presence of caffeine as internal standard. A Hiber®, RP-18 column was used with mobile phase consisting of acetonitrile:methanol:water (30:20:50 v/v, pH 3.6) and quantitative evaluation was performed at 230 run. Suitability of this method for the quantitative determination of the drugs was proved by validation in accordance with the requirements laid down by International Conference on Harmonization (ICH) guidelines.The method was selective, precise, accurate and can be used for routine analysis of pharmaceutical preparations, quality control and clinical laboratories.
dc.formattext/html
dc.languageen
dc.publisherSociedad Chilena de Química
dc.sourceJournal of the Chilean Chemical Society v.54 n.4 2009
dc.subjectDiltiazem
dc.subjectfloroquinolones
dc.subjectmethod validation
dc.subjectHPLC determination
dc.titleA RP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF DILTIAZEM AND QUINOLONES IN BULK, FORMULATIONS AND HUMAN SERUM
dc.typeArtículos de revistas


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