Artículos de revistas
Resistencia inducible a clindamicina en Staphylococcus aureus meticilino resistente
Autor
MONTOYA C,IRENE
MIRA O,MAGDALENA
ÁLVAREZ A,ISABEL
COFRE G,JOSÉ
COHEN V,JACOB
DONOSO W,GLORIA
TORRES T,JUAN PABLO
Institución
Resumen
The increase in methicillin-resistant Staphylococcus aureus (MRSA) infections has limited the use of efective available antibiotics. Clindamycin, an alternative against MRSA, might have inducible resistance that is not detected by common antibiograms. The disk diffusion method (D-test) detects the inducible resistance. Objetive: To establish the frecuency of inducible resistance in MRSA from blood and secretion samples obtained from hospitalyzed patients. Methods: Prospective and descriptive research, including MRSA positive blood and secretion samples from patients of Hospital Luis Calvo Mackenna, between July 2005-July 2006. A D-test was performed to the samples. Results: 220 MRSA samples were obtained and D-test was performed on 155 of them. 80% of the samples carne from tracheobronquial secretion and 90%> had used antibiotics. From all analyzed MRSA isolates, 32 (20.6%o) were Clindamycin susceptible and 14 (43.8%) had Clindamycin inducible resistance (D-test+). Conclusions: A high percentage of MRSA Clindamycin resistant was found. From MRSA Clindamycin susceptible, 43.8%> had Clindamycin inducible resistance (D test+). D-test was implemented in the Microbiology Laboratory at Hospital Luis Calvo Mackenna, allowing the identification of MRSA isolates suceptible to Clindamicyn treatment.