| dc.creator | TORAL,M. INÉS | |
| dc.creator | RIVAS,JORGE | |
| dc.creator | SALDÍAS,MARTA | |
| dc.creator | SOTO,CÉSAR | |
| dc.creator | ORELLANA,SANDRA | |
| dc.date | 2008-06-01 | |
| dc.date.accessioned | 2017-03-07T16:09:55Z | |
| dc.date.available | 2017-03-07T16:09:55Z | |
| dc.identifier | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000200022 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/397161 | |
| dc.description | A rapid method for the simultaneous determination of acetaminophen (A) and tramadol (T) by second derivative spectrophotometric has been developed. From a solvent effect studies and the spectral behaviours of A and T, ethanol was selected as solvent. For a Δλ value of 210 nm a smoothing factor of 8,000 and scale factor of 1,000,000 were selected, because in these conditions the signal/noise ratio was favoured in order to avoid error. In these conditions also it is possible the simultaneous determination of A/T in a molar relation of 17/1 contained in pharmaceutical formulations. At 285.7 nm the second derivative value is T concentration dependent, corresponding to zero-crossing point of A. On the other hand, T does not absorb between 296.0 to 400.0 nm, thus 308.0 nm was selected for A determination by graphic method. The determination ranges for A and T were 8.1x10-7 - 5 1x10-5 mol/L and 3.4 x10-7 - 5.0 x10-5 mol/L, respectively and can be determined with good precision and accuracy, without previous separation. A study of interferents, was carried out by using the excipients Zafin® tablet. The recoveries were 97.4 ± 2.0% and 100.6 ± 1.7% for A and T, respectively. This tablet containing both drugs was assayed using the methods developed, showing a good accuracy and precision. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad Chilena de Química | |
| dc.source | Journal of the Chilean Chemical Society v.53 n.2 2008 | |
| dc.subject | Acetaminophen | |
| dc.subject | Tramadol | |
| dc.subject | Simultaneous Determination | |
| dc.subject | Derivative Spectrophotometry | |
| dc.subject | Pharmaceutical Formulation | |
| dc.title | SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN AND TRAMADOL BY SECOND DERIVATIVE SPECTROPHOTOMETRY | |
| dc.type | Artículos de revistas | |
