SCAVENGING ACTIVITY OF DICLOFENAC: INTERACTION WITH ABTS RADICAL CATION AND PEROXYL RADICALS

dc.creatorROJO,C
dc.creatorÁLVAREZ-FIGUEROA,M. J
dc.creatorSOTO,M
dc.creatorCAÑETE,A
dc.creatorPESSOA-MAHANA,D
dc.creatorLÓPEZ-ALARCÓN,C
dc.date2009-01-01
dc.date.accessioned2017-03-07T16:08:25Z
dc.date.available2017-03-07T16:08:25Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000100014
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/396777
dc.descriptionThe scavenging activity of diclofenac was estimated by its capability to bleach ABTS radical cation, and ORAC (oxygen radical absorbance capacity) methodology. In addition, GC-MS technique was used to establish if the lactamic derivative of diclofenac was formed as final product in the interaction with peroxyl radicals. Diclofenac bleached ABTS radical cation in a concentration-dependent way. In ORAC assays, diclofenac inhibited the consumption of fluorescein and c-phycocyanin mediated by peroxyl radicals. An ORAC-fluorescein, and ORAC-c-phycocyanin value of 0.3, and 0.004 was estimated, respectively. From the downcurvature observed in Stern-Volmer-like plots, we postulated that the low protection of c-phycocyanin is related to secondary damage of c-phycocyanin by the secondary radical of diclofenac. By GC-MS studies only a 2,6-dichloroaniline derivative was detected as product afterthe reaction with peroxyl radicals.
dc.formattext/html
dc.languageen
dc.publisherSociedad Chilena de Química
dc.sourceJournal of the Chilean Chemical Society v.54 n.1 2009
dc.subjectDiclofenac
dc.subjectfluorescein
dc.subjectc-phycocyanin
dc.subjectORAC
dc.subjectscavenging activity
dc.titleSCAVENGING ACTIVITY OF DICLOFENAC: INTERACTION WITH ABTS RADICAL CATION AND PEROXYL RADICALS
dc.typeArtículos de revistas


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