A VOLTAMMETRIC STUDY ON THE INTERACTION OF NOVOBIOCIN WITH CYSTEINE

dc.creatorBÇER,ENDER
dc.creatorQETNKAYA,PAKZE
dc.date2009-01-01
dc.date.accessioned2017-03-07T16:08:24Z
dc.date.available2017-03-07T16:08:24Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000100011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/396774
dc.descriptionThe interaction of novobiocin (NOV), an aminocoumarin antibiotic, with cysteine was studied by square-wave voltammetry technique on the hanging mercury drop electrode in different pH values. After the addition of NOV into the cysteine solution, the peak current of mercurous cysteine thiolate decreased and its voltammetric peak potential shifted to more positive values. Voltammetric results showed that NOV binds with cysteine forming 1:1 nonelectroactive molecular complex by means of electrostatic and hydrogen-bonding interactions. The binding constants of NOV with cysteine at pHs 5, 7 and 10 were calculated to be 3.06x10³, 1.54x10(4) and 1.06x10(5) M-1, respectively. Furthermore, apossible mechanism of such interaction was also discussed.
dc.formattext/html
dc.languageen
dc.publisherSociedad Chilena de Química
dc.sourceJournal of the Chilean Chemical Society v.54 n.1 2009
dc.subjectVoltammetry
dc.subjectNovobiocin
dc.subjectCysteine
dc.subjectInteraction
dc.subjectpH effect
dc.titleA VOLTAMMETRIC STUDY ON THE INTERACTION OF NOVOBIOCIN WITH CYSTEINE
dc.typeArtículos de revistas


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