| dc.creator | Marini,Guillermo | |
| dc.creator | Forno,Guillermina | |
| dc.creator | Kratje,Ricardo | |
| dc.creator | Etcheverrigaray,Marina | |
| dc.date | 2007-04-01 | |
| dc.date.accessioned | 2017-03-07T15:54:52Z | |
| dc.date.available | 2017-03-07T15:54:52Z | |
| dc.identifier | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000200011 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/392888 | |
| dc.description | The pharmacokinetic behaviour of the non-glycosylated, bacterially-derived recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and the glycosylated mammalian product was studied after intra and extra vascular administration of a single dose in rodents. Each route of administration gave a different rhGM-CSF concentration-time profile. After extra vascular administration of equivalent doses, a higher peak concentration and faster elimination were observed in the group treated with the E. coli-derived cytokine. The faster elimination resulted in a return to pre-treatment plasma levels after 12 hrs, versus 48 hrs following the administration of glycosylated rhGM-CSF. After intravascular administration, clearance of rhGM-CSF was significantly decreased by the presence of carbohydrates. Non-significant differences in the terminal phase of the biphasic kinetics were found, but the distribution phase was significantly longer for the glycosylated form | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Pontificia Universidad Católica de Valparaíso | |
| dc.source | Electronic Journal of Biotechnology v.10 n.2 2007 | |
| dc.subject | glycosylation | |
| dc.subject | pharmacokinetic parameters | |
| dc.subject | rhGM-CSF | |
| dc.title | Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters | |
| dc.type | Artículos de revistas | |
