SYNTHESIS AND CONFORMATIONAL ANALYSIS OF LEPTOCARPIN DERIVATIVES: INFLUENCE OF MODIFICATION OF THE OXIRANE RINGON LEPTOCARPIN'S CYTOTOXIC ACTIVITY

dc.creatorMARTÍNEZ,ROLANDO
dc.creatorKESTERNICH,VICTOR
dc.creatorCARRACSO,HÉCTOR
dc.creatorÁLVAREZ-CONTRERAS,CAROLINA
dc.creatorMONTENEGRO,CAROLINA
dc.creatorUGARTE,RICARDO
dc.creatorGUTIÉRREZ,ELENA
dc.creatorMORENO,JOSÉ
dc.creatorGARCÍA,CARLOS
dc.creatorWERNER,ENRIQUE
dc.creatorCÁRCAMOS,JUAN
dc.date2006-12-01
dc.date.accessioned2017-03-07T15:46:27Z
dc.date.available2017-03-07T15:46:27Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000400003
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/390669
dc.descriptionThe reaction in acidconditions of Leptocarpin 1, a compound with antitumor activity, formed two new isomeric products, 8b-angeloyl-1b,3b-dihydroxy-4,10-dimethyl,-D11(13) methylen-4Z,9Z-dieneheliangol-6,12-olide 2 and 8b-angeloyl-1b,3b-dihydroxy-4-methyl-D11(13),D11(14)-dimethylen-4Z-eneheliangol-6,12-olide 3, whose structures reported in this study were established by spectroscopy (¹H-NMR, 13C-NMR, MS and IR) and confirmedthrough ROESY experiments and theoretical studies by molecular mechanics. The in vitro cytotoxicity of these isomeric compounds was less active than leptocarpin, showing the importance of the oxirane ring in the biological activity. Cytotoxic activity was measured in six cancer cell lines
dc.formattext/html
dc.languageen
dc.publisherSociedad Chilena de Química
dc.sourceJournal of the Chilean Chemical Society v.51 n.4 2006
dc.subjectConformational analysis
dc.subjectHeliangolide
dc.subjectSesquiterpene lactones
dc.subjectCytotoxicity
dc.titleSYNTHESIS AND CONFORMATIONAL ANALYSIS OF LEPTOCARPIN DERIVATIVES: INFLUENCE OF MODIFICATION OF THE OXIRANE RINGON LEPTOCARPIN'S CYTOTOXIC ACTIVITY
dc.typeArtículos de revistas


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