Antioxidant responses of cortex neurons to iron loading

dc.creatorAGUIRRE,PABLA
dc.creatorMENA,NATALIA
dc.creatorTAPIA,VICTORIA
dc.creatorROJAS,ALEJANDRO
dc.creatorARREDONDO,MIGUEL
dc.creatorNÚÑEZ,MARCO TULIO
dc.date2006-01-01
dc.date.accessioned2017-03-07T15:38:18Z
dc.date.available2017-03-07T15:38:18Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100012
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/388531
dc.descriptionBrain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione levels. In this work, in cortical neurons we characterized viability and changes in reduced and oxidized glutathione levels in response to a protocol of iron accumulation. We found that massive death occurred after 2 days in culture with 10 mM Fe. Surviving cells developed an adaptative response that included increased synthesis of GSH and the maintenance of a glutathione-based reduction potential. These results highlight the fundamental role of glutathione homeostasis in the antioxidant response and provide novel insights into the adaptative mechanisms of neurons subjected to progressive iron loads.
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.sourceBiological Research v.39 n.1 2006
dc.subjectglutathione
dc.subjectiron
dc.subjectredox response
dc.subjectcortical neurons
dc.subjectcell death
dc.titleAntioxidant responses of cortex neurons to iron loading
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución