| dc.creator | AVALOS,ANA MARIA | |
| dc.creator | LABRA,CECILIA V. | |
| dc.creator | QUEST,ANDREW F.G. | |
| dc.creator | LEYTON,LISSETTE | |
| dc.date | 2002-01-01 | |
| dc.date.accessioned | 2017-03-07T15:12:55Z | |
| dc.date.available | 2017-03-07T15:12:55Z | |
| dc.identifier | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200015 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/380278 | |
| dc.description | Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand. Recently described evidence that Thy-1 interacts with ß3 integrin on astrocytes will be discussed. Thy-1 binding to ß3 integrin triggers tyrosine phosphorylation of focal adhesion proteins in astrocytes, thereby promoting focal adhesion formation, cell attachment and spreading. Thy-1 has been reported to modulate neurite outgrowth by triggering a cellular response in neurons. However, our data indicate that Thy-1 can also initiate signaling events that promote adhesion of adjacent astrocytes to the underlying surface. Preliminary results suggest that morphological changes observed in the actin cytoskeleton of astrocytes as a consequence of Thy-1 binding is mediated by small GTPases from the Rho family. Our findings argue that Thy-1 functions in a bimodal fashion, as a receptor on neuronal cells and as a ligand for ß3 integrin receptor on astrocytes. Since Thy-1 is implicated in the inhibition of neurite outgrowth, signaling events in astrocytes are likely to play an important role in this process | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.source | Biological Research v.35 n.2 2002 | |
| dc.subject | Thy-1 ligand/integrins | |
| dc.subject | GPI-anchored proteins | |
| dc.subject | strocytes | |
| dc.subject | focal adhesion | |
| dc.title | Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function | |
| dc.type | Artículos de revistas | |
