Studies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonets

dc.creatorWALLACE,ANNE
dc.creatorORTÍZ,SILVIA
dc.creatorSÁNCHEZ,GITTITH
dc.creatorVILLAGRA,REBECA
dc.creatorMUGA,MABEL
dc.creatorSOLARI,ALDO
dc.date2001-01-01
dc.date.accessioned2017-03-07T15:10:16Z
dc.date.available2017-03-07T15:10:16Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/379333
dc.descriptionThe biological characterization of bloodstream forms of eleven Trypanosoma cruzi cloned stocks, corresponding to two genetically similar clonets (<A HREF="#19">19</A> and <A HREF="#20">20</A>) and one distant clonet (39), according to multilocus enzyme electrophoresis analysis, showed dissimilar parasitemia in an experimental isogenic mouse model. While clonet 39 stocks gave low parasitemias, clonets 19 or 20 stocks gave high parasitemias, independently of the inocula (10² and 10(4) bloodstream forms) used. High parasitemia did not always associate with greater mortality. Statistical studies on mortality using a low inocula showed significantly higher mortality with clonet 39 stocks when compared to clonets 19 or 20 stocks. Finally, in order to confirm the identity of each stock studied, typing by molecular karyotype was performed before inoculating mice.
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.sourceBiological Research v.34 n.2 2001
dc.subjectTrypanosoma cruzi
dc.subjectclonets
dc.subjectparasitemia
dc.subjectmortality
dc.subjectbloodstream forms
dc.subjectmultilocus enzyme electrophoresis
dc.titleStudies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonets
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución