A new mulinane diterpenoid from the cushion shrub Azorella compacta growing in Peru

dc.creatorSalgado, F.
dc.creatorAreche, C.
dc.creatorSepulveda, B.
dc.creatorSimirgiotis, MJ.
dc.creatorCaceres, F.
dc.creatorQuispe, C.
dc.creatorQuispe, L.
dc.creatorCano, T.
dc.date2014-12-18T13:39:38Z
dc.date2014-12-18T13:39:38Z
dc.date2014-08
dc.date.accessioned2017-03-07T15:01:59Z
dc.date.available2017-03-07T15:01:59Z
dc.identifierPHARMACOGNOSY MAGAZINE 10 (39) : 543-548
dc.identifier0976-4062
dc.identifierhttp://dspace.utalca.cl/handle/1950/10160
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/377069
dc.descriptionUniv Talca, Inst Nat Resources, Lab Nat Prod Chem, Talca, Chile. Quispe, C (Quispe, Cristina)
dc.descriptionBackground: Azorella compacta is a rare yellow-green compact resinous cushion shrub growing from the high Andes of southern Per to northwestern Argentina, and which is a producer of biologically active and unique diterpenoids. Objective: This study investigated the secondary metabolites present in a Peruvian sample of Azorella compacta and the evaluation of gastroprotective activity of the isolated compounds in a gastric-induced ulcer model in mice. Material and Methods: Six secondary metabolites (diterpenoids 1-6) present in the dichloromethane (DCM) extract of A. compacta growing in Per were isolated by a combination of Sephadex LH-20 permeation and silica gel chromatography and their chemical structures were elucidated by spectroscopic methods (NMR) and molecular modeling. The gastroprotective activity of the new compound 1 was evaluated on the HCl/EtOH-induced gastric lesion model in mice and compared to the activity showed by the known compounds. Results: A new mulinane diterpene along with five known diterpenoids have been isolated from a Peruvian sample of A. compacta and the gastroprotective results show that compound 1 is less active than the other known mulinane diterpenoids isolated. Conclusions: A. compacta growing in Per showed the presence of the new mulinane 1, which was poorly active in the HCl/EtOH-induced gastric lesion model in mice. Indeed, the activity was lower than other diterpenoids (2-6) showing an oxygenated function at C-16 or/and C-20, which confirm the role of an oxygenated group (OH or carboxylic acid) for the gastroprotective activity of mulinane compounds.
dc.languageen
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTD
dc.subjectgastroprotective activity
dc.subjectmulinanes
dc.subjectApiaceae
dc.subjectazorella compacta
dc.subjectditerpenoids
dc.titleA new mulinane diterpenoid from the cushion shrub Azorella compacta growing in Peru
dc.typeArtículos de revistas


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