Antimicrobial phenylpropanoids from the Argentinean highland plant Parastrephia lucida (Meyen) Cabrera

dc.creatorD'Almeida, R.E.
dc.creatorAlberto, M.R.
dc.creatorQuispe, C.
dc.creatorSchmeda-Hirschmann, G.
dc.creatorIsla, M.I.
dc.date2012-12-17T19:28:49Z
dc.date2012-12-17T19:28:49Z
dc.date2012-07
dc.date.accessioned2017-03-07T14:59:06Z
dc.date.available2017-03-07T14:59:06Z
dc.identifierJOURNAL OF ETHNOPHARMACOLOGY Volume: 142 Issue: 2 Pages: 407-414
dc.identifier0378-8741
dc.identifierhttp://dspace.utalca.cl/handle/1950/9156
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/376024
dc.descriptionQuispe, C (Quispe, Cristina); Schmeda-Hirschmann, G (Schmeda-Hirschmann, Guillermo). Univ Talca, Inst Quim Recursos Nat, Talca, Chile
dc.descriptionEthnopharmacological relevance: The Argentinean highland plant Parastrephia lucida (Meyen) Cabrera is used in traditional medicine as an antiseptic and anti-inflammatory crude drug. Aim of the study: To relate the antimicrobial effect of the crude drug with the constituents of the active fractions and traditional use. Materials and methods: Assay-guided isolation of the methanol (MeOH) plant extract was carried out using bacteria and yeasts as target organisms. Both ATCC and local strains were included in the study. The antimicrobial fractions and compounds were detected by bioautographic assays. Minimum inhibitory concentrations (MIC) of each extract and fraction were determined and compared with reference antibiotics. Fractions were analyzed by HPLC-DAD, GC-MS, H-1 NMR and C-13 NMR. Results: From the MeOH extract of the plant, assay-guided isolation of the antimicrobial constituents led to 12 phenylpropanoids and two simple phenolics. Most of the compounds occurring in the active fractions were E-caffeoyl or E-cinnamoyl esters including prenyl and phenethyl derivatives. The MIC values of the most active fractions ranged between 12.5 and 200 mu g/mL against reference strains and local isolates of Staphylococcus aureus and Enterococcus faecalis. Conclusions: The antimicrobial effect found in the crude drug was associated with mixtures of phenylpropanoids, including prenyl and phenethyl esters of caffeic and cinnamic acids. The results support at least in part the traditional use of the plant as local antiseptic. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
dc.languageen
dc.publisherELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
dc.subjectParastrephia lucida
dc.subjectAsteraceae
dc.subjectAntimicrobial activity
dc.subjectPhenylpropanoids
dc.titleAntimicrobial phenylpropanoids from the Argentinean highland plant Parastrephia lucida (Meyen) Cabrera
dc.typeArtículos de revistas


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