Artículos de revistas
The mechanism of Sandmeyer's cyclization reaction by electrospray ionization mass spectrometry
Registro en:
RAPID COMMUNICATIONS IN MASS SPECTROMETRY Volume: 25 Issue: 3 Pages: 423-428 DOI: 10.1002/rcm.4869
0951-4198
Autor
Silva, B.V.
Violante, F.A.
Pinto, A.C.
Santos, L.S.
Institución
Resumen
Santos, LS (reprint author), Talca Univ, Lab Asymmetr Synth, Chem Inst Nat Resources, POB 747, Talca, Chile. Using electrospray ionization (tandem) mass spectrometry (ESI-MS(/MS)) spectrometric experiments, the Sandmeyer reaction was monitored on-line, and key intermediates were intercepted and characterized for the first time. The mechanistic information provided by on-line ESI-MS(/MS) is in accordance with Sandmeyer's proposal, and was made possible by coupling a microreactor on-line to the ESI ion source, which allowed reactions to be screened from 0.7-2.0 s, identifying and characterizing all intermediates that were formed and consumed during the reaction. Copyright (C) 2011 John Wiley & Sons, Ltd.