Artículos de revistas
3-Dipolar Cycloaddition of Nitrile Imines with Cyclic alpha-beta-Unsaturated Ketones: A Regiochemical Route to Ring-Fused Pyrazoles
Registro en:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY Issue: 25 Pages: 4806-4813 DOI: 10.1002/ejoc.201100558
1434-193X
Autor
Chandanshive, J.Z.
Bonini, B.F.
Tiznado, W.
Escobar, C.A.
Caballero, J.
Femoni, C.
Fochi, M.
Franchini, M.C.
Institución
Resumen
Caballero, J (Caballero, Julio). Univ Talca, Ctr Bioinformt & Simulac Mol, Fac Ingn Bioinformat, Talca, Chile 1,3-Dipolar cycloadditions of C-carboxymethyl-N-arylnitrile
imines with cyclic α,β-unsaturated ketones of various sizes
have been studied. After cycloaddition, oxidative aromatization
gives the ring-fused pyrazoles. Computational studies and the use of topological analyses of the Fukui functions
allows a theoretical description of the local reactivity that is
in agreement with the experimentally observed regiochemistry