| dc.creator | Schmeda-Hirschmann, G. | |
| dc.creator | Loyola, J.I. | |
| dc.creator | Rodriguez, J. | |
| dc.creator | Dutra-Behrens, M. | |
| dc.date | 2008-03-10T16:59:56Z | |
| dc.date | 2008-03-10T16:59:56Z | |
| dc.date | 1994 | |
| dc.date.accessioned | 2017-03-07T14:45:26Z | |
| dc.date.available | 2017-03-07T14:45:26Z | |
| dc.identifier | Phytotherapy Research 8 (1): 49-51 | |
| dc.identifier | 0951-418X | |
| dc.identifier | http://dspace.utalca.cl/handle/1950/4621 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/372299 | |
| dc.description | G. Schmeda-Hirschmann, J. I. Loyola, J. Rodriguez, M. Departamento de Ciencias Biolögicas, Universidad de Talca, Casilla 747, Talca, Chile. | |
| dc.description | The leaves of Laurelia sempervirens (Monimiaceae), an endemic Chilean tree known as Laurel, were used by the Mapuche Amerindians for treating headache and as a diuretic. Intravenous administration of a hydroalcoholic L. sempervirens extract to rats, elicited a hypotensive response of -27.0%±2.0% in the mean blood pressure of normotensive animals at a dose of 5 mg crude extract ± kg body weight. Bioassay-guided isolation of the active Laurel metabolites led to the alkaloid laurotetanine as the main hypotensive principle of L. sempervirens leaves. At 1 mg/kg body weight, laurotetanine produced a hypotensive response of -29.0%±2.1% in the mean blood pressure of normotensive rats, with a duration of 2 min, both comparable to those elicited by the crude extract at 5 mg/kg. In the acute oral toxicity study, Laurel proved to be a very low toxicity crude drug at doses up to 3 g crude extract/kg body weight. The data obtained support the use of L. sempervirens in Mapuche traditional medicine. | |
| dc.format | 2974 bytes | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | John Wiley & Sons Ltd. | |
| dc.subject | Laurelia sempervirens; Monimiaceae; hypotensive effect; oral toxicity in rats: laurotetanine; alkaloids. | |
| dc.title | Hypotensive effect of Laurelia sempervirens (Monimiaceae) on normotensive rats | |
| dc.type | Artículos de revistas | |
