Biologically active alkaloids and a free radical scavenger from Prosopis species

dc.creatorTapia, A.
dc.creatorFeresin, G.E.
dc.creatorBustos, D.
dc.creatorAstudillo, L.
dc.creatorTheoduloz, C.
dc.creatorSchmeda-Hirschmann, G.
dc.date2008-03-05T16:02:05Z
dc.date2008-03-05T16:02:05Z
dc.date2000
dc.date.accessioned2017-03-07T14:45:15Z
dc.date.available2017-03-07T14:45:15Z
dc.identifierJournal of Ethnopharmacology 71 (1-2): 241-246
dc.identifier0378-8741
dc.identifierhttp://dspace.utalca.cl/handle/1950/4582
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/372259
dc.descriptionLuis Astudillo, Cristina Theoduloz and Guillermo Schmeda-Hirschmann. Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.
dc.descriptionAbstract The biological activity of extracts from the aerial parts of five Argentinian Prosopis species and the exudate of P. flexuosa were assessed for DNA binding, β-glucosidase inhibition and free radical scavenging effect using the DPPH decoloration assay. DNA binding effect was found mainly in the basic fraction. The alkaloids tryptamine as well as piperidine and phenethylamine derivatives were isolated from the basic extracts. At 0.50 mg/ml, DNA binding activities ranged from 28% for tryptamine to 0–27% for the phenethylamine and 47–54% for the piperidine derivatives. Tryptamine and 2-β-methyl-3-β-hydroxy-6-β-piperidinedodecanol showed a moderate inhibition (27–32%) of the enzyme β-glucosidase at 100 μg/ml. The exudate of P. flexuosa displayed a strong free radical scavenger effect in the DPPH decoloration assay. The main active constituent was identified as catechin.
dc.format2977 bytes
dc.formattext/html
dc.languageen
dc.publisherElsevier Science Ireland Ltd.
dc.subjectProsopis alpataco; Prosopis argentina; Prosopis chilensis; Prosopis flexuosa; Prosopis pugionata; DNA binding; β-glucosidase inhibition; Free radical scavengers; Alkaloids; Catechin
dc.titleBiologically active alkaloids and a free radical scavenger from Prosopis species
dc.typeArtículos de revistas


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