| dc.creator | Reyes, M. | |
| dc.creator | Schmeda-Hirschmann, G. | |
| dc.creator | Razmilic, I. | |
| dc.creator | Theoduloz, C. | |
| dc.creator | Yanez, T. | |
| dc.creator | Rodriguez, J. | |
| dc.date | 2007-12-26T22:05:50Z | |
| dc.date | 2007-12-26T22:05:50Z | |
| dc.date | 2005 | |
| dc.date.accessioned | 2017-03-07T14:44:06Z | |
| dc.date.available | 2017-03-07T14:44:06Z | |
| dc.identifier | Phytotherapy Research 19(12):1038 - 1042 | |
| dc.identifier | 0951-418X | |
| dc.identifier | http://dspace.utalca.cl/handle/1950/4280 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/371971 | |
| dc.description | Reyes, M.; Schmeda-Hirschmann, G.; Razmilic, I.
Laboratorio de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.
Theoduloz, C.; Yáñez, T.; Rodríguez, J. Departamento de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca, Casilla 747, Talca, Chile. | |
| dc.description | An infusion or decoction of the aerial parts of Fabiana imbricata (Solanaceae) is used in traditional medicine in Chile and Argentina as a digestive and diuretic agent. The main sesquiterpene of the plant was identified as 11-hydroxy-4-amorphen-15-oic acid. At doses of 25, 50 and 100 mg/kg, the compound showed a dose-dependent gastroprotective effect in HCl/EtOH-induced gastric lesions in mice reducing the lesions by 68% at 100 mg/kg. Seven derivatives of the terpene were prepared and their gastroprotective effect was assessed in HCl/EtOH-induced gastric lesions in mice. The cytotoxicity of the products was evaluated in fibroblasts and AGS cells. At 100 mg/kg, 11-hydroxy-4-amorphen-15-p-toluidinamide presented the best gastroprotective effect reducing the gastric lesions by 80%, showing a similar effect to lansoprazole at 20 mg/kg. The compound, however, presented higher cytotoxicity than other derivatives with the IC50 ranging between 110 and 145 µm in AGS cells and fibroblasts, respectively. Most compounds proved to be non-toxic showing cytotoxicity values higher than 1000 µm. The spectroscopic data of six 11-hydroxy-4-amorphen-15-oic acid derivatives are presented here for the first time. | |
| dc.format | 2942 bytes | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | John Wiley & Sons Ltd. | |
| dc.subject | Fabiana imbricata; Solanaceae; 11-hydroxy-4-amorphen-15-oic acid; sesquiterpene derivatives; gastroprotective effect; cytotoxicity | |
| dc.title | Gastroprotective activity of sesquiterpene derivatives from Fabiana imbricata | |
| dc.type | Artículos de revistas | |
