| dc.creator | Schmeda-Hirschmann, G. | |
| dc.creator | Rodriguez, J. | |
| dc.creator | Astudillo, L. | |
| dc.date | 2007-11-26T16:04:32Z | |
| dc.date | 2007-11-26T16:04:32Z | |
| dc.date | 2002 | |
| dc.date.accessioned | 2017-03-07T14:43:21Z | |
| dc.date.available | 2017-03-07T14:43:21Z | |
| dc.identifier | Journal of Ethnopharmacology 81(1): 111-115 | |
| dc.identifier | 0378-8741 | |
| dc.identifier | http://dspace.utalca.cl/handle/1950/4080 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/371785 | |
| dc.description | Schmeda-Hirschmann, G.; Astudillo L. Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla Talca, 747, Chile.
Rodriguez, J. Instituto de Biología Vegetal y Biotecnología, Universidad de Talca, Casilla 747, Talca, Chile. | |
| dc.description | The labdane diterpene solidagenone 1 and its semisynthetic and biotransformations products 2–7 were assessed for gastroprotective effect in the HCl·EtOH-induced lesions in mice. At 100 mg/kg, solidagenone presented a statistically significant gastroprotective effect (P<0.05) comparable to lansoprazole at 20 mg/kg. The presence of the furan ring was required for the activity of solidagenone while hydroxylation at C-3 or C-6 afforded products with different activity associated with the stereochemistry. Solidagen-6β-ol 7 and 3α-hydroxysolidagenone 2 presented higher activity than solidagenone itself, while its epimers were inactive | |
| dc.format | 2941 bytes | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Elsevier Science Ireland Ltd. | |
| dc.subject | Solidagenone; Labdane diterpenes; Semisynthesis; Solidagen-6β-ol; Gastroprotective effect | |
| dc.title | Gastroprotective activity of the diterpene solidagenone and its derivatives on experimentally induced gastric lesions in mice | |
| dc.type | Artículos de revistas | |
