| dc.creator | Feresin, G.E. | |
| dc.creator | Tapia, A. | |
| dc.creator | Sortino, M. | |
| dc.creator | Zacchino, S. | |
| dc.creator | De Arias, A.R. | |
| dc.creator | Inchaustti, A. | |
| dc.creator | Yaluff, G. | |
| dc.creator | Rodriguez, J. | |
| dc.creator | Theoduloz, C. | |
| dc.creator | Schmeda-Hirschmann, G. | |
| dc.date | 2007-11-23T22:13:36Z | |
| dc.date | 2007-11-23T22:13:36Z | |
| dc.date | 2003 | |
| dc.date.accessioned | 2017-03-07T14:43:16Z | |
| dc.date.available | 2017-03-07T14:43:16Z | |
| dc.identifier | Journal of Ethnopharmacology 88 (2-3): 241-247 | |
| dc.identifier | 0378-8741 | |
| dc.identifier | http://dspace.utalca.cl/handle/1950/4078 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/371761 | |
| dc.description | Rodriguez,J.;Theoduloz,C. Laboratorio de Cultivo Celular, Facultad de Ciencias de la Salud, Universidad de Talca, Casilla 747, Talca, Chile
Schmeda-Hirschmann, G. Natural Products Chemistry Laboratory, Institute of Chemistry of Natural Resources, University of Talca, Talca, Chile. | |
| dc.description | The benzoquinone embelin and four alkyl phenols were isolated from an Argentinean collection of Oxalis erythrorhiza. 3-Heptadecyl-5-methoxy-phenol is reported for the first time. The structures were determined by spectroscopic methods. Embelin presented inhibitory effect on methicillin-resistant Staphylococcus aureus, Escherichia coli and the dermatophytic fungi Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes and Trichophyton rubrum with MICs ranging between 50 and 100 μg/ml. Furthermore, embelin was active against Trypanosoma cruzi trypomastigotes with 100% lysis at 100 μg/ml and cytotoxicity below the trypanocidal concentration. The new alkyl phenol 3-heptadecyl-5-methoxy-phenol was active towards Leishmania amazonensis and Leishmania donovani promastigotes with 100% lysis at 100 μg/ml. The cytotoxicity (IC50) of embelin and the new alkyl phenol on human lung fibroblasts were 739 and 366 μM, respectively. The plant is used to treat heart complains, a symptomatology related to Chagas’ disease which is endemic in the San Juan Province, Argentine. | |
| dc.format | 2941 bytes | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Elsevier Ireland Ltd | |
| dc.subject | Oxalis erythrorhiza; Oxalidaceae; Embelin; Alkyl phenols; Antimicrobial and antiprotozoal activity | |
| dc.title | Bioactive alkyl phenols and embelin from Oxalis erythrorhiza | |
| dc.type | Artículos de revistas | |
