Van Diejen, J.F. (reprint author). Instituto de Matemática y Física, Universidad de Talca, Casilla 747, Talca, Chile.To a crystallographic root system we associate a system of multivariate orthogonal polynomials diagonalizing an integrable system of discrete pseudo Laplacians on the Weyl chamber. We develop the time-dependent scattering theory for these discrete pseudo Laplacians and determine the corresponding wave operators and scattering operators in closed form. As an application, we describe the scattering behavior of certain hyperbolic Ruijsenaars-Schneider type lattice Calogero-Moser models associated with the Macdonald polynomials.