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        COVID-19 and Diabetes; possible role of polymorphism and rise of telemedicine

        Registration in:
        1751-9918
        https://doi.org/10.1016/j.pcd.2020.08.018
        http://hdl.handle.net/20.500.12010/12820
        https://doi.org/10.1016/j.pcd.2020.08.018
        http://repositorioslatinoamericanos.uchile.cl/handle/2250/3506715
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        Author
        Sayed, Shomoita
        Institutions
        • Universidad Jorge Tadeo Lozano (Colombia)
        Abstract
        Background: Diabetes has been found to be one of the leading comorbidities associated with fatality in COVID-19 patients. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry is facilitated by interaction with Angiotensin Converting Enzyme-2 (ACE2) and possible polymorphisms in ACE2 can be a determining factor in host-viral protein interaction. A significant shift of healthcare towards ‘Telemedicine’ is also on the rise. In this review, the possible effects of ACE2 polymorphisms on SARSCoV-2 entry along with the escalation of ‘telemedicine’ is discussed. Method: An expansive literature search using keywords: “COVID-19”, “SARS-CoV-2”, “diabetes”, “type 2 diabetes’’, “type 1 diabetes”, “ACE2”, “polymorphism”, “DPP4” and “telemedicine” was conducted on Pubmed and EMBASE till 7th August, 2020. Result: Possible polymorphisms in ACE2 gene can play a role in influencing the virus entry in host body. Telemedicine can be bring a new revolution for medical sector. Conclusion: COVID-19 severity is more heinous among diabetic population. So far, the in-silico studies involving human ACE2-viral Spike (S) interaction showed inconsistent predictions regarding some SNPs. But without actual in-vivo studies, a holistic understanding can’t be established.
        Subjects
        COVID-19
        Diabetes
        ACE2
        SNP
        Polymorphism
        Telemedicine

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        Red de Repositorios Latinoamericanos
        + of 4.000.000
        Available publications
        163 Participating institutions
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Membership Login
        Featured collections
        • Latin American Theses
        • Argentinean Theses
        • Chilean Theses
        • Peruvian Theses
        Latest collections added
        • Argentina
        • Brazil
        • Colombia
        • México
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Red de Repositorios Latinoamericanos | 2006-2018