COVID-19 and Diabetes; possible role of polymorphism and rise of telemedicine
Autor
Sayed, Shomoita
Institución
Resumen
Background: Diabetes has been found to be one of the leading comorbidities associated with fatality in
COVID-19 patients. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry is facilitated
by interaction with Angiotensin Converting Enzyme-2 (ACE2) and possible polymorphisms in ACE2 can
be a determining factor in host-viral protein interaction. A significant shift of healthcare towards
‘Telemedicine’ is also on the rise. In this review, the possible effects of ACE2 polymorphisms on SARSCoV-2 entry along with the escalation of ‘telemedicine’ is discussed.
Method: An expansive literature search using keywords: “COVID-19”, “SARS-CoV-2”, “diabetes”, “type
2 diabetes’’, “type 1 diabetes”, “ACE2”, “polymorphism”, “DPP4” and “telemedicine” was conducted on
Pubmed and EMBASE till 7th August, 2020.
Result: Possible polymorphisms in ACE2 gene can play a role in influencing the virus entry in host body.
Telemedicine can be bring a new revolution for medical sector.
Conclusion: COVID-19 severity is more heinous among diabetic population. So far, the in-silico studies
involving human ACE2-viral Spike (S) interaction showed inconsistent predictions regarding some SNPs.
But without actual in-vivo studies, a holistic understanding can’t be established.