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        • Colombia
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        • Universidad Jorge Tadeo Lozano (Colombia)
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        • Universidad Jorge Tadeo Lozano (Colombia)
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        Network pharmacology suggests biochemical rationale for treating covid-19 symptoms with a traditional chinese medicine

        Registro en:
        2399-3642
        https://doi.org/10.1038/s42003-020-01190-y
        http://hdl.handle.net/20.500.12010/13359
        https://doi.org/10.1038/s42003-020-01190-y
        http://repositorioslatinoamericanos.uchile.cl/handle/2250/3496935
        Autor
        Zhang, Deng-hai
        Zhang, Xue
        Peng, Bin
        Deng, Sheng-qiong
        Wang, Yu-fang
        Yang, Lin
        Zhang, Kai-zheng
        Ling, Chang-quan
        Wu, Kun-lun
        Institución
        • Universidad Jorge Tadeo Lozano (Colombia)
        Resumen
        hinese herbal formulas including the lung-cleaning and toxicity-excluding (LCTE) soup have played an important role in treating the ongoing COVID-19 pandemic (caused by SARS-CoV2) in China. Applying LCTE outside of China may prove challenging due to the unfamiliar rationale behind its application in terms of Traditional Chinese Medicine. To overcome this barrier, a biochemical understanding of the clinical effects of LCTE is needed. Here, we explore the chemical compounds present in the reported LCTE ingredients and the proteins targeted by these compounds via a network pharmacology analysis. Our results indicate that LCTE contains compounds with the potential to directly inhibit SARS-CoV-2 and inflammation, and that the compound targets proteins highly related to COVID-19’s main symptoms. We predict the general effect of LCTE is to affect the pathways involved in viral and other microbial infections, inflammation/cytokine response, and lung diseases. Our work provides a biochemical basis for using LCTE to treat COVID-19 and its main symptoms.
        Materias
        Network pharmacology
        COVID-19
        Chinese medicine

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        Red de Repositorios Latinoamericanos
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        Red de Repositorios Latinoamericanos
        + de 8.000.000 publicaciones disponibles
        500 instituciones participantes
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Ingreso Administradores
        Colecciones destacadas
        • Tesis latinoamericanas
        • Tesis argentinas
        • Tesis chilenas
        • Tesis peruanas
        Nuevas incorporaciones
        • Argentina
        • Brasil
        • Colombia
        • México
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Red de Repositorios Latinoamericanos | 2006-2018