dc.creator | Zhang, Deng-hai | |
dc.creator | Zhang, Xue | |
dc.creator | Peng, Bin | |
dc.creator | Deng, Sheng-qiong | |
dc.creator | Wang, Yu-fang | |
dc.creator | Yang, Lin | |
dc.creator | Zhang, Kai-zheng | |
dc.creator | Ling, Chang-quan | |
dc.creator | Wu, Kun-lun | |
dc.date.accessioned | 2020-09-17T15:55:10Z | |
dc.date.accessioned | 2022-09-23T18:10:56Z | |
dc.date.available | 2020-09-17T15:55:10Z | |
dc.date.available | 2022-09-23T18:10:56Z | |
dc.date.created | 2020-09-17T15:55:10Z | |
dc.identifier | 2399-3642 | |
dc.identifier | https://doi.org/10.1038/s42003-020-01190-y | |
dc.identifier | http://hdl.handle.net/20.500.12010/13359 | |
dc.identifier | https://doi.org/10.1038/s42003-020-01190-y | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3496935 | |
dc.description.abstract | hinese herbal formulas including the lung-cleaning and toxicity-excluding (LCTE) soup have
played an important role in treating the ongoing COVID-19 pandemic (caused by SARS-CoV2) in China. Applying LCTE outside of China may prove challenging due to the unfamiliar
rationale behind its application in terms of Traditional Chinese Medicine. To overcome this
barrier, a biochemical understanding of the clinical effects of LCTE is needed. Here, we
explore the chemical compounds present in the reported LCTE ingredients and the proteins
targeted by these compounds via a network pharmacology analysis. Our results indicate that
LCTE contains compounds with the potential to directly inhibit SARS-CoV-2 and inflammation, and that the compound targets proteins highly related to COVID-19’s main symptoms.
We predict the general effect of LCTE is to affect the pathways involved in viral and other
microbial infections, inflammation/cytokine response, and lung diseases. Our work provides a
biochemical basis for using LCTE to treat COVID-19 and its main symptoms. | |
dc.language | eng | |
dc.publisher | Communications biology | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | Abierto (Texto Completo) | |
dc.source | reponame:Expeditio Repositorio Institucional UJTL | |
dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | |
dc.subject | Network pharmacology | |
dc.subject | COVID-19 | |
dc.subject | Chinese medicine | |
dc.title | Network pharmacology suggests biochemical rationale for treating covid-19 symptoms with a traditional chinese medicine | |