Comparison of the QuantiFERON-TB and tuberculin skin test for detection of latent tuberculosis infection in cancer patients of a developing country

Abstract

Cancer patients have an increased risk of reactivation of latent tuberculosis infection, it is unknown which strategy on screening should be used in this population in developing countries. We aimed to determine the concordance between the tuberculin skin test and QuantiFERON-TB assay in order to diagnose latent tuberculosis infection in cancer patients. We conducted a cross-sectional study of agreement of diagnostic tests. Prevalence and agreement between tests were calculated. A logistic regression to assess predictors of discordance was performed. The accuracy of the tuberculin skin test to predict QuantiFERON-TB results by ROC curve was evaluated. We included 149 adults with cancer without active tuberculosis. Prevalence of latent tuberculosis infection was 21.5% (n=32), defined as positive results on either test. Tests agreement was moderate for the diagnosis of latent tuberculosis infection (κ=0.43, 90% CI 0.26-0.6). No predictor was associated with the chance of discordant results. Agreement improved slightly using a cut-off point ≥8 mm (κ=0.5, 90% CI 0.35-0.66). In moderate-incidence setting, a moderate agreement was found between tests in cancer patients. Modification of cut-off points of test results achieve marginally better agreement between TST and QFT.