dc.creator | Castiblanco, John | |
dc.creator | Varela, Diana-Cristina | |
dc.creator | Castaño-Rodríguez, Natalia | |
dc.creator | Rojas-Villarraga, Adriana | |
dc.creator | Hincapié, María-Eugenia | |
dc.creator | Anaya, Juan-Manuel | |
dc.date.accessioned | 2020-05-26T00:11:31Z | |
dc.date.accessioned | 2022-09-22T15:09:59Z | |
dc.date.available | 2020-05-26T00:11:31Z | |
dc.date.available | 2022-09-22T15:09:59Z | |
dc.date.created | 2020-05-26T00:11:31Z | |
dc.identifier | 15671348 | |
dc.identifier | https://repository.urosario.edu.co/handle/10336/24308 | |
dc.identifier | https://doi.org/10.1016/j.meegid.2008.03.001 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3445645 | |
dc.description.abstract | Background and aim: The involvement of Toll-like receptor (TLR)-mediated pathways in infectious and autoimmunity has been suggested. The MyD88 adaptor-like (Mal) protein, also known as the TIR domain-containing adaptor protein (TIRAP), is implicated in the TLR2- and TLR4-mediated MyD88-dependent signaling pathway. The aim of this study was to investigate the influence of the functional TIRAP (MAL) S180L polymorphism on tuberculosis (TB) and four autoimmune diseases namely: rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1D). Methods: This was a case-control and family based association study in which 1325 individuals from a well-defined Colombian population were involved. TIRAP (MAL) S180L genotyping was done by using a polymerase chain reaction-restriction fragment length polymorphism technique and by direct sequencing. Results: Leu180 allele was found to be a protective factor against developing TB (odd ratio (OR): 0.53, 95% confidence interval (CI): 0.29-0.97) and SLE (OR: 0.29, 95% CI: 0.14-0.61) while no significant influence on RA, pSS and T1D was observed. Conclusion: These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response. © 2008 Elsevier B.V. All rights reserved. | |
dc.language | eng | |
dc.relation | Infection, Genetics and Evolution, ISSN:15671348, Vol.8, No.5 (2008); pp. 541-544 | |
dc.relation | https://www.scopus.com/inward/record.uri?eid=2-s2.0-46749097334&doi=10.1016%2fj.meegid.2008.03.001&partnerID=40&md5=b93dfe0b884d0fc662eb3b63f8c7ec7d | |
dc.relation | 544 | |
dc.relation | No. 5 | |
dc.relation | 541 | |
dc.relation | Infection, Genetics and Evolution | |
dc.relation | Vol. 8 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | Abierto (Texto Completo) | |
dc.source | instname:Universidad del Rosario | |
dc.source | reponame:Repositorio Institucional EdocUR | |
dc.title | TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus | |
dc.type | article | |