dc.creator | Chuaire-Noack L. | |
dc.creator | Rondón-Lagos S. | |
dc.creator | Sánchez-Corredor M. | |
dc.creator | Ibáñez-Pinilla M. | |
dc.creator | Ramírez-Clavijo, Sandra | |
dc.date.accessioned | 2020-05-25T23:55:43Z | |
dc.date.accessioned | 2022-09-22T14:55:16Z | |
dc.date.available | 2020-05-25T23:55:43Z | |
dc.date.available | 2022-09-22T14:55:16Z | |
dc.date.created | 2020-05-25T23:55:43Z | |
dc.identifier | 5355133 | |
dc.identifier | https://repository.urosario.edu.co/handle/10336/22187 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3443389 | |
dc.description.abstract | ?-galactosidase activity reflects the rate of cellular aging in vitro. Such activity was quantified at pH 6 in ovarian epithelial cells from 28 donors without a history of cancer, by the chemoluminiscent method. The cells were serially cultured until they achieved the state of permanent growth arrest. During the exponential growth phase, all cultures showed a similar pattern of growth and low ?-galactosidase activity. However, both in the onset of decrease replicative activity, as well as in the onset of the stationary phase, there was a significant rise in the enzyme activity. Our results showed that ?-galactosidase activity can be considered as a replicative senescence marker of the ovarian surface epithelium at pH 6. | |
dc.language | spa | |
dc.relation | Investigacion Clinica, ISSN:5355133, Vol.51, No.3 (2010); pp. 351-367 | |
dc.relation | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78650437743&partnerID=40&md5=f83177e886dd4b79fb81810d8481812d | |
dc.relation | 367 | |
dc.relation | No. 3 | |
dc.relation | 351 | |
dc.relation | Investigacion Clinica | |
dc.relation | Vol. 51 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | Abierto (Texto Completo) | |
dc.source | instname:Universidad del Rosario | |
dc.source | reponame:Repositorio Institucional EdocUR | |
dc.title | ?-galactosidase activity as a marker of senescence in primary cultures of the ovarian surface epithelium | |
dc.type | article | |