Caracterización del material hiperreflectivo subretiniano en pacientes con degeneración macular relacionada con la edad neovascular tratados con antiangiogénicos

Abstract

Purpose: To analyze the morphological characteristics of subretinal hyperreflective material (SHRM) and short-term visual outcomes in patients with neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial grown factor (anti-VEGF) at the Fundacion Oftalmologica Nacional between 2011 and 2017. Methodology: Descriptive longitudinal study, including 65 patients with previously untreated nAMD, between January 2011 and December 2017. The structural optical coherence tomography (OCT) was reviewed to determine quantitative and qualitative characteristics of SHRM, and best corrected visual acuity (BCVA) in LogMAR before and after treatment. Results: The median age was 76 years (range 68-84). The majority of patients were women in 56.9%. The laterality of the most affected eye was the right in 50.8%. Aflibercept was the most widely used antiangiogenic in 40% of the patients. The median BCVA was 0.7 (range 0.5-1.2) logMAR and 0.7 (range 0.4-1) logMAR at baseline and after treatment, respectively. The baseline parameters with a positive correlation by bivariate analysis before and after treatment were the BCVA, reflectivity, edges and extension of the SHRM. The parameters that were associated with an improvement in BCVA after treatment were the presence of the ellipsoid zone (EZ) and external limiting membrane (ELM), reflectivity, homogeneity and extension of the SHRM. Conclusion: This study provides tomographic features of the SRHM associated with short-term visual outcomes in eyes with nAMD treated with anti-VEGF.