Estrategias de prevención y tratamiento del síndrome postreperfusión en paciente adulto con trasplante hepático de donante cadavérico. Revisión sistemática

Abstract

Introduction: Liver transplantation is the only option against the definitive loss of metabolic function of the liver caused by various causes. With the implementation, of this process, a nee scenario appears, such as the survival and improvement of quality of life, for the affected patient. One of the techniques for obtaining an organ suitable for transplantation includes an organ from a deceased donor. The surgical procedure has a variable incidence of reperfusion syndrome, which consists of a set of hemodynamic and metabolic changes that occur in the transition from the anhepatic to the neohepatic phase, it is believed that the ischemia-reperfusion injury, which is the lesion Cellular tissue from a transplanted organ in response to prolonged ischemia plays an important role in post-perfusion syndrome. Objective: Therefore, the information regarding current prevention and treatment strategies for post-perfusion syndrome in a deceased donor liver transplant patient was synthesized. Methodology Systematic literature review, taking into account aspects such as title, abstract and the data processing and methodology used by authors, based on studies that address current strategies for the prevention and treatment of post-perfusion syndrome in patients with liver transplantation from a deceased donor, by posing the research question and defining the primary outcome , the definition of the sources of information, selection of the articles in the databases, Taking into account aspects such as title, abstract and the data processing , methodology used by authors, and the results of each study, analysis of the information obtained in the studies, extraction of the information, and presentation of the results obtained. Results: The perfusion machine, mannitol, α-linoleic acid and N-acetylcysteine are currently used as a form of prevention of post-perfusion syndrome, in terms of treatment the use of tacrolimus did not generate statistically significant results, other treatments usually used studies were found with low heterogeneity, and not eligible for systematic review.