Caracterización de pacientes con enfermedad de Parkinson en un centro de referencia de la ciudad de Bogotá, Colombia

Abstract

Introduction: Parkinson's disease is one of the most prevalent neurodegenerative diseases worldwide. It's clinical presentation, motor and non-motor signs have been described previously. In our population, we don't know the frequency of those signs and symptoms. Objective: Describe the clinical presentation, motor and non-motor signs of a cohort of patients with Parkinson's disease, that were evaluated in a movement disorders center of reference, at Bogotá, Colombia. Materials and methods: Descriptive retrospective study of patients with Parkinson's disease, who went to the movement disorders clinic between January 2013 and June 2015. Patients were organized depending on the time from the onset of the disease. Socio-demographic variables, motor and non-motor signs and symptoms where studied. Frequencies, mean and proportions were analyzed using SPSS 22 version. Results: 446 patients were analyzed, from which 50.7% were women. The mean age found was 68 years old. We found hiposmia in 33.6% of patients and abnormalities in REM sleep in 32% of them. The first motor symptoms noticed by the patient were tremor (62.3%), bradykinesia (15.9%), stiffness (12.6%), difficulty walking (8.1%), balance problems (1.6%) and falls (1.6%). Conclusion: Parkinson's disease is the second most frequent neurodegenerative disease worldwide. Its clinical presentation is diverse, and in our population we have never study the patterns of presentation. We found similar frequencies compared with the international registries of this disease, with some difference in demographic and non-motor symptoms.